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Welcome
ESO continues to update our curated collection of resources relevant for the treatment of stroke during the COVID-19 global pandemic. We hope you will find this page valuable. #StrokeStillMatters
As further publications and studies emerge, this resource continues to grow. Please check back at the end of each month for the most recent publications. We encourage submissions of COVID-19 resources to be considered for inclusion. Please send the source and link to esoinfo@eso-stroke.org.
Stroke and COVID-19
Publications Relevant for Stroke Diagnosis and Management
Updated September 2021
COVID-19 Vaccination and Cerebrovascular Events
Original Articles/Case Reports - All Vaccines
- Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. Hippisley-Cox J. etal. BMJ. 2021 Aug 26;374:n1931.
- Vaccines against Covid-19, venous thromboembolism, and thrombocytopenia. A population-based retrospective cohort study. Laporte J-R et al., medRxiv 2021.07.23.21261036.
- SARS-CoV-2-vaccination Cerebral Venous Sinus Thrombosis: an analysis of cases notified to the European Medicines Agency. Katarzyna Krzywicka et al. 22 July 2021.
Original Articles/Case Reports - AstraZeneca Vaccine
- Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. Pavord S. et al. N Engl J Med. 2021 Aug 11.
- Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Perry R.J. et al. Lancet. 2021 Aug 6:S0140-6736(21)01608-1.
- Prothrombotic immune thrombocytopenia after COVID-19 vaccination. Tiede A. et al. Blood. 2021 Jul 29;138(4):350-353
- Thrombotic Thrombocytopenia and Central Venous Sinus Thrombosis Post – COVID-19 Vaccination and its Treatment with Heparin Alternatives. Sheikh S. et al. J Coll Physicians Surg Pak. 2021 Jul;31(7):149.
- Fatal cerebral venous sinus thrombosis after COVID-19 vaccination. Jamme M, Mosnino E. et al. Intensive Care Med. 2021 Jul;47(7):790-791.
- Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopaenia. Al-Mayhani T. et al. Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 May 2021.
- Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19. Castelli G.P. et al. Crit Care. 2021 Apr 12;25(1):137. .
- US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, See I. et al. March 2 to April 21, 2021. JAMA. Published online April 30, 2021.
- Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study. Pottegård A. et al. BMJ. 2021 May 5;373:n1114.
- Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. Scully M. et al. N Engl J Med. 2021 Apr 16.
- Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. Greinacher A et al. N Engl J Med. 2021 Apr 9.
- Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. Schultz N.H. et al. N Engl J Med. 2021 Apr 9.
- Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). Greinacher A. et al.
Original Articles / Case Reports - Johnson and Johnson/Janssen Vaccine
- Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine. Malik B. et al. BMJ Case Rep. 2021 Jul 14;14(7):e243975.
- US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. See I et al JAMA. 2021 Jun 22;325(24):2448-2456.
- Advisory Committee on Immunization Practices. Reports of cerebral venous sinus thrombosis with thrombocytopenia after Janssen COVID-19 vaccine. National Center for Immunization & Respiratory Diseases. . April 12, 2021
- Thrombotic thrombocytopenia after Ad26.COV2.S vaccination. Muir K-L et al. N Engl J Med.
- Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – Response from the Manufacturer. Sadoff J. et al. N Engl J Med. 2021 Apr 16.
Original Articles / Case Reports - Moderna Vaccine
- Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry. Giannis D. et al. Blood 2021; blood.2020010529.
- Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine. Helms J.M. et al. J Blood Med. 2021 Apr 6;12:221-224.
- Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Bayas A. et al. . Lancet. 2021;S0140-6736(21)00872-2.
- Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. Guendouz C. et al. Medicine (Baltimore). 2021 Mar 12;100(10):e24708.
Original Articles / Case Reports - Pfizer/Biontech Vaccine
- Polack F.P. et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020 Dec 31;383(27):2603-2615.
- Taquet M. et al. Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. [preprint]
Guidance
- Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis: A Review. Rizk J.G. et al. JAMA Cardiol. 2021 Aug 10. doi: 10.1001/jamacardio.2021.3444. Epub ahead of print. PMID: 34374713.
- European stroke organisation interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination. Ferro JM et al. European Stroke Journal. July 2021. doi:10.1177/23969873211030842
- Brighton collaboration diagnostic guidelines https://brightoncollaboration.us/wp-content/uploads/2021/05/TTS-Interim-Case-Definition-v10.16.3-May-23-2021.pdf
- American Heart Association/American Stroke Association Stroke Council Leadership. Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia. Stroke. 2021 Apr 29.
- Oldenburg J. et al. Diagnosis and management of vaccine-related thrombosis following astrazeneca covid-19 vaccination: Guidance statement from the GTH. Hamostaseologie. 2021.
- UK Guidance produced by the Expert Haematology Panel (EHP) focussed on Vaccine induced Thrombosis and Thrombocytopenia (VITT)
- UK Management of cerebral venous sinus thrombosis following Covid-19 vaccination A neurosurgical guide
Comments and Editorials
- Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine. Karron RA et al. JAMA. 2021 Jun 22;325(24):2445-2447.
- Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): What We Know and Don’t Know. Arepally G.M. et al. Blood. 2021 Jun 1:blood.2021012152.
- Ischaemic stroke can follow COVID-19 vaccination but is much more common with COVID-19 infection itself. Markus H.S. J Neurol Neurosurg Psychiatry. 2021 May 25:jnnp-2021-327057.
- SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. Cines D.B. et al. N Engl J Med. 2021 Apr 16.
- Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination. Douxfils J. et al. Thromb Res. 2021 Jul;203:163–71.
Venous thromboembolism after vaccination or COVID-19
- Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review. Tu T.M. et al. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105379.
- Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis. Baldini T. et al. Eur J Neurol. 2021 Jan 11:10.1111/ene.14727.
- Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry Giannis et al. Preprint as .pdf
- Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. Taquet M et al. Preprint
Updated July 2021
Additional Publications on COVID-19 and Stroke
July 2021 - Original Articles
- Global impact of COVID-19 on stroke care. Nogueira et al. Int J Stroke. 2021 Jul;16(5):573-584.
- Changes in Patterns of Hospital Visits for Acute Myocardial Infarction or Ischemic Stroke During COVID-19 Surges. Solomon MD et al. JAMA. 2021 Jul 6;326(1):82-84.
- 4C Mortality Score correlates with in-hospital functional outcome after COVID-19-associated ischaemic stroke.Sawczyńska K. et al. Neurol Neurochir. 2021 May 5.
- Intracerebral hemorrhage in COVID-19: A narrative review. Margos NP et al. J Clin Neurosci. 2021 Jul;89:271-278.
- Impact of the COVID-19 pandemic and post-epidemic periods on the process of endovascular treatment for acute anterior circulation ischaemic stroke. Zhang T. et al. BMC Neurol. 2021 Jun 24;21(1):238.
- Acute symptomatic seizures and COVID-19: Hospital-based study Khedr EM et al. Epilepsy Res. 2021 Aug;174:106650.
- Attendance for ischaemic stroke before and during COVID-19 lockdown in Singapore. Narasimhalu K. et al. Ann Acad Med Singap. 2021 Apr;50(4):359-361
- Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: A study at two stroke centers in Egypt. Aref HM et al. PLoS One. 2021 Jul 14;16(7):e0254228.
- The Impact of the COVID-19 Public Health Crisis on Communication and Quality of Life: Insights From a Community of Stroke and Brain Trauma Survivors. Fama ME et al. Am J Speech Lang Pathol. 2021 Jul 14;30(4):1805-1818.
- Racial and Ethnic Disparities in Heart and Cerebrovascular Disease Deaths During the COVID-19 Pandemic in the United States. Wadhera RK et al. Circulation. 2021 Jun 15;143(24):2346-2354.
- COVID-19 Reveals Opportunities for Better Care of Stroke Patients. Studer B et al. Dtsch Arztebl Int. 2021 May 17;118(19):346-347.
- Stroke management during the COVID-19 outbreak: challenges and results of a hub-center in Lombardy, Italy.Asteggiano F et al. Neuroradiology. 2021 Jul;63(7):1087-1091.
- Delayed Stroke Treatment during COVID-19 Pandemic in China. Gu S et al. Cerebrovasc Dis. 2021 Jul 9:1-7.
- Risk Factors, and Clinical and Etiological Characteristics of Ischemic Strokes in COVID-19-Infected Patients: A Systematic Review of Literature. Vidale S. Cerebrovasc Dis. 2021;50(4):371-374.
July 2021 - Comment and Editorials
Original Articles
Guidance
Comments and Editorials
The collected publications have been suggested by members of the Paper of the Month working group. ESO members can also nominate a paper for inclusion in this resource.
