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Welcome
ESO continues to update our curated collection of resources relevant for the treatment of stroke during the COVID-19 global pandemic. We hope you will find this page valuable. #StrokeStillMatters
As further publications and studies emerge, this resource continues to grow. Please check back at the end of each month for the most recent publications. We encourage submissions of COVID-19 resources to be considered for inclusion. Please send the source and link to esoinfo@eso-stroke.org.
Stroke and COVID-19
Abstract
Severe cases of cerebral venous thrombosis (CVT) with thrombocytopenia and anti-platelet factor 4 (PF4) antibodies occurring after adenoviral vector anti-SARS-CoV-2 vaccines have been recently reported. We aim to present a guidance document on the diagnosis and treatment of patients presenting with CVT after vaccination against SARS-CoV-2 infection. We reviewed the available evidence which consists on case reports, small case series, expert opinion and analogy with heparin-induced thrombocytopenia (HIT) management. Because of the low level of evidence, this is an interim document, based only on expert opinion consensus.
Publications Relevant for Stroke Diagnosis and Management
COVID-19 Vaccination and Cerebrovascular Events
Original Articles/Case Reports - All Vaccines
- Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. Hippisley-Cox J. etal. BMJ. 2021 Aug 26;374:n1931.
- Vaccines against Covid-19, venous thromboembolism, and thrombocytopenia. A population-based retrospective cohort study. Laporte J-R et al., medRxiv 2021.07.23.21261036.
- SARS-CoV-2-vaccination Cerebral Venous Sinus Thrombosis: an analysis of cases notified to the European Medicines Agency. Katarzyna Krzywicka et al. 22 July 2021.
Original Articles/Case Reports - AstraZeneca Vaccine
- Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. Pavord S. et al. N Engl J Med. 2021 Aug 11.
- Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Perry R.J. et al. Lancet. 2021 Aug 6:S0140-6736(21)01608-1.
- Prothrombotic immune thrombocytopenia after COVID-19 vaccination. Tiede A. et al. Blood. 2021 Jul 29;138(4):350-353
- Thrombotic Thrombocytopenia and Central Venous Sinus Thrombosis Post – COVID-19 Vaccination and its Treatment with Heparin Alternatives. Sheikh S. et al. J Coll Physicians Surg Pak. 2021 Jul;31(7):149.
- Fatal cerebral venous sinus thrombosis after COVID-19 vaccination. Jamme M, Mosnino E. et al. Intensive Care Med. 2021 Jul;47(7):790-791.
- Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopaenia. Al-Mayhani T. et al. Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 May 2021.
- Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19. Castelli G.P. et al. Crit Care. 2021 Apr 12;25(1):137. .
- US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, See I. et al. March 2 to April 21, 2021. JAMA. Published online April 30, 2021.
- Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study. Pottegård A. et al. BMJ. 2021 May 5;373:n1114.
- Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. Scully M. et al. N Engl J Med. 2021 Apr 16.
- Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. Greinacher A et al. N Engl J Med. 2021 Apr 9.
- Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. Schultz N.H. et al. N Engl J Med. 2021 Apr 9.
- Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). Greinacher A. et al.
Original Articles / Case Reports - Johnson and Johnson/Janssen Vaccine
- Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine. Malik B. et al. BMJ Case Rep. 2021 Jul 14;14(7):e243975.
- US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. See I et al JAMA. 2021 Jun 22;325(24):2448-2456.
- Advisory Committee on Immunization Practices. Reports of cerebral venous sinus thrombosis with thrombocytopenia after Janssen COVID-19 vaccine. National Center for Immunization & Respiratory Diseases. . April 12, 2021
- Thrombotic thrombocytopenia after Ad26.COV2.S vaccination. Muir K-L et al. N Engl J Med.
- Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – Response from the Manufacturer. Sadoff J. et al. N Engl J Med. 2021 Apr 16.
Original Articles / Case Reports - Moderna Vaccine
- Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry. Giannis D. et al. Blood 2021; blood.2020010529.
- Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine. Helms J.M. et al. J Blood Med. 2021 Apr 6;12:221-224.
- Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Bayas A. et al. . Lancet. 2021;S0140-6736(21)00872-2.
- Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. Guendouz C. et al. Medicine (Baltimore). 2021 Mar 12;100(10):e24708.
Original Articles / Case Reports - Pfizer/Biontech Vaccine
- Polack F.P. et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020 Dec 31;383(27):2603-2615.
- Taquet M. et al. Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. [preprint]
Guidance
- Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis: A Review. Rizk J.G. et al. JAMA Cardiol. 2021 Aug 10. doi: 10.1001/jamacardio.2021.3444. Epub ahead of print. PMID: 34374713.
- European stroke organisation interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination. Ferro JM et al. European Stroke Journal. July 2021. doi:10.1177/23969873211030842
- Brighton collaboration diagnostic guidelines https://brightoncollaboration.us/wp-content/uploads/2021/05/TTS-Interim-Case-Definition-v10.16.3-May-23-2021.pdf
- American Heart Association/American Stroke Association Stroke Council Leadership. Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia. Stroke. 2021 Apr 29.
- Oldenburg J. et al. Diagnosis and management of vaccine-related thrombosis following astrazeneca covid-19 vaccination: Guidance statement from the GTH. Hamostaseologie. 2021.
- UK Guidance produced by the Expert Haematology Panel (EHP) focussed on Vaccine induced Thrombosis and Thrombocytopenia (VITT)
- UK Management of cerebral venous sinus thrombosis following Covid-19 vaccination A neurosurgical guide
Comments and Editorials
- Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine. Karron RA et al. JAMA. 2021 Jun 22;325(24):2445-2447.
- Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): What We Know and Don’t Know. Arepally G.M. et al. Blood. 2021 Jun 1:blood.2021012152.
- Ischaemic stroke can follow COVID-19 vaccination but is much more common with COVID-19 infection itself. Markus H.S. J Neurol Neurosurg Psychiatry. 2021 May 25:jnnp-2021-327057.
- SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. Cines D.B. et al. N Engl J Med. 2021 Apr 16.
- Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination. Douxfils J. et al. Thromb Res. 2021 Jul;203:163–71.
Venous thromboembolism after vaccination or COVID-19
- Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review. Tu T.M. et al. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105379.
- Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis. Baldini T. et al. Eur J Neurol. 2021 Jan 11:10.1111/ene.14727.
- Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry Giannis et al. Preprint as .pdf
- Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. Taquet M et al. Preprint
Publications on COVID-19 and Stroke
Original Articles
- Global impact of COVID-19 on stroke care. Nogueira et al. Int J Stroke. 2021 Jul;16(5):573-584.
- Changes in Patterns of Hospital Visits for Acute Myocardial Infarction or Ischemic Stroke During COVID-19 Surges. Solomon MD et al. JAMA. 2021 Jul 6;326(1):82-84.
- 4C Mortality Score correlates with in-hospital functional outcome after COVID-19-associated ischaemic stroke.Sawczyńska K. et al. Neurol Neurochir. 2021 May 5.
- Intracerebral hemorrhage in COVID-19: A narrative review. Margos NP et al. J Clin Neurosci. 2021 Jul;89:271-278.
- Impact of the COVID-19 pandemic and post-epidemic periods on the process of endovascular treatment for acute anterior circulation ischaemic stroke. Zhang T. et al. BMC Neurol. 2021 Jun 24;21(1):238.
- Acute symptomatic seizures and COVID-19: Hospital-based study Khedr EM et al. Epilepsy Res. 2021 Aug;174:106650.
- Attendance for ischaemic stroke before and during COVID-19 lockdown in Singapore. Narasimhalu K. et al. Ann Acad Med Singap. 2021 Apr;50(4):359-361
- Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: A study at two stroke centers in Egypt. Aref HM et al. PLoS One. 2021 Jul 14;16(7):e0254228.
- The Impact of the COVID-19 Public Health Crisis on Communication and Quality of Life: Insights From a Community of Stroke and Brain Trauma Survivors. Fama ME et al. Am J Speech Lang Pathol. 2021 Jul 14;30(4):1805-1818.
- Racial and Ethnic Disparities in Heart and Cerebrovascular Disease Deaths During the COVID-19 Pandemic in the United States. Wadhera RK et al. Circulation. 2021 Jun 15;143(24):2346-2354.
- COVID-19 Reveals Opportunities for Better Care of Stroke Patients. Studer B et al. Dtsch Arztebl Int. 2021 May 17;118(19):346-347.
- Stroke management during the COVID-19 outbreak: challenges and results of a hub-center in Lombardy, Italy.Asteggiano F et al. Neuroradiology. 2021 Jul;63(7):1087-1091.
- Delayed Stroke Treatment during COVID-19 Pandemic in China. Gu S et al. Cerebrovasc Dis. 2021 Jul 9:1-7.
- Risk Factors, and Clinical and Etiological Characteristics of Ischemic Strokes in COVID-19-Infected Patients: A Systematic Review of Literature. Vidale S. Cerebrovasc Dis. 2021;50(4):371-374.
- Stroke Patients’ Characteristics and Clinical Outcomes: A Pre-Post COVID-19 Comparison Study. Loh H.C. et al. Medicina (Kaunas). 2021 May 19;57(5):507.
- Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. Stroke. McAlpine L.S. et al. 2021 Jun;52(6):e233-e238.
- Ischemic stroke associated with aneurysmal lenticulostriate vasculopathy and symmetric reversible basal ganglia lesions in COVID-19. Strause J. et al. J Neurol Sci. 2021 Jul 15;426:117484.
- Stroke Care in the United Kingdom During the COVID-19 Pandemic. Douiri A. et al. SSNAP Collaboration. Stroke. 2021 Apr 26:STROKEAHA120032253.
- Acute Coronary Syndrome and Ischemic Stroke Discharges in the United States During the COVID-19 Pandemic. de Havenon A. et al. Stroke. 2021 Jun;52(6):e239-e241.
- Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke. Patel U. et al. J Stroke Cerebrovasc Dis. 2021 Jul;30(7):105805.
- Consideration Needed for early Anticoagulation Following Intravenous tPA in Patients with COVID-19. Jimenez A. et al. J Stroke Cerebrovasc Dis. 2021 Jul;30(7):105769.
- Changes in Patterns of Hospital Visits for Acute Myocardial Infarction or Ischemic Stroke During COVID-19 Surges. Solomon M.D. et al. JAMA. 2021 Jun 2.
- Increased quality of life in patients with stroke during the COVID-19 pandemic: a matched-pair study. Zhao L. et al. Sci Rep. 2021 May 13;11(1):10277.
- COVID-19 infection produces subarachnoid hemorrhage; acting now to understand its cause: A short communication. Batcik O.E. et al. Clin Neurol Neurosurg. 2021 Mar;202:106495.
- Impact of cerebral venous sinus thrombosis associated with COVID-19. Hinduja A. et al. J Neurol Sci. 2021 Jun 15;425:117448.
- Impact of COVID-19 pandemic on patients with large-vessel vasculitis in Italy: a monocentric survey. Tomelleri A. et al. Ann Rheum Dis. 2020 Sep;79(9):1252-1253.
- Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia. Ramos-Pachón A. et al.Cerebrovasc Dis. 2021 May 21:1-9.
- Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature. Mohamad A. et al.
Journal of Stroke and Cerebrovascular Diseases, Volume 30, Issue 6, 2021 - Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes During the Early COVID-19 Pandemic. Wallace A.N. et al. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105569.
- Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. Stroke. McAlpine L.S. et al. 2021 Jun;52(6):e233-e238.
- SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group. Shahjouei S. et al. 2021 May;52(5):e117-e130.
- Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature. Abdalkader M. et al. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105733.
- Stroke Care in the United Kingdom During the COVID-19 Pandemic. Douiri A. et al. SSNAP Collaboration. Stroke. 2021 Apr 26:STROKEAHA120032253.
- Successful conduct of an acute stroke clinical trial during COVID. Yamal J.M. et al. PLoS One. 2021 Jan 15;16(1):e0243603.
- Higher Mortality of Ischaemic Stroke Patients Hospitalized with COVID-19 Compared to Historical Controls. Harrison S.L et al. Cerebrovasc Dis. 2021 Mar 26:1-6.
- SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group. Shahjouei S. et al. Stroke. 2021 May;52(5):e117-e130.
- Vozmozhnosti povysheniya effektivnosti terapii patsientov s khronicheskoi ishemiei golovnogo mozga na fone COVID-19 [Possibilities of improving the effectiveness of therapy in patients with chronic cerebral ischemia against the background of COVID-19]. Kovalchuk V.V. et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(3. Vyp. 2):60-66. Russian.
- A meta-analysis of the global impact of the COVID-19 pandemic on stroke care & the Houston Experience. Reddy S.T. et al. Ann Clin Transl Neurol. 2021 Apr;8(4):929-937.
- The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis. Honardoost M. et al. Cerebrovasc Dis. 2021;50(2):132-140.
- Impact of COVID-19 Pandemic on a Regional Stroke Thrombectomy Service in the United Kingdom. Kwan J. et al. Cerebrovasc Dis. 2021;50(2):178-184.
- SARS-Cov-2-fertőzés szövődményeként kialakult enormis nagyságú carotisthrombus kezelési lehetőségei [Treatment options for enormous carotid thrombus as a complication of SARS-CoV-2 infection]. Koncz J. et al. Ideggyogy Sz. 2021 Mar 30;74(3-4):129-134. Hungarian.
- Is home-based therapy in Fabry disease the answer to compelling patients’ needs during the COVID-19 pandemic? Survey results from the Polish FD Collaborative Group. Kusztal M. et al. Adv Clin Exp Med. 2021 Apr;30(4):449-454.
- Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men. Tu T.M. et al. JAMA Netw Open. 2021 Apr 1;4(4):e217498.
- The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis. Honardoost M. et al. Cerebrovasc Dis. 2021;50(2):132-140.
- Adaptive Approach to Endovascular Management of Large Vessel Occlusion During the COVID-19 Pandemic. Tabibian B.E. et al. J Stroke Cerebrovasc Dis. 2021 May;30(5):105642.
- Outcomes of COVID-19 complications and their possibilities as potential triggers of stroke. Patel U. et al. J Stroke Cerebrovasc Dis. 2021 Apr 8:105805.
- Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza. Merkler A.E. et al. JAMA Neurol. 2020;77(11):1366–1372.
- Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis – a systematic review and meta-analysis. Syahrul S. et al. F1000Res. 2021 Jan 19;10:34.
- Impact of the COVID-19 Pandemic on Stroke Epidemiology and Clinical Stroke Practice in the US. Friedlich D. et al. J Stroke Cerebrovasc Dis. 2021 Apr;30(4):105639.
- Acute Ischemic Stroke in Patients With COVID-19: An Analysis From Get With The Guidelines-Stroke. Srivastava P.K. et al. Stroke. 2021 Mar 17:STROKEAHA121034301.
- Cerebral venous thrombosis in a patient with mild COVID-19 infection. Pang Y.Z. et al. Ann Acad Med Singap. 2021 Feb;50(2):188-190.
- Nervous system diseases are associated with the severity and mortality of patients with COVID-19: a systematic review and meta-analysis. Gao Y. et al. Epidemiol Infect. 2021 Feb 15;149:e66.
- Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network. Brunetti V. et al. Neurol Sci. 2021 Apr;42(4):1237-1245.
- Neurologic Syndromes Predict Higher In-Hospital Mortality in COVID-19. Eskandar E.N. et al. Neurology. 2021 Mar 16;96(11):e1527-e1538.
- Hospitalizations for Stroke in France During the COVID-19 Pandemic Before, During, and After the National Lockdown. Mariet A.S. et al. Stroke. 2021 Apr;52(4):1362-1369.
- Regional Changes in Patterns of Stroke Presentation During the COVID-19 Pandemic. Etherton M.R. et al. Stroke. 2021 Apr;52(4):1398-1406.
- Impact of COVID-19 on the rate of stroke cases at a tertiary hospital in Makkah, Saudi Arabia. Samkari E.T et al. Neurosciences (Riyadh). 2021 Apr;26(2):158-162.
- COVID-19 infection and stroke risk. Sadeghmousavi S. et al. Rev Neurosci. 2020 Dec 24;32(3):341-349.
- Changes in Prehospital Stroke Care and Stroke Mimic Patterns during the COVID-19 Lockdown. Melaika K et al. Int J Environ Res Public Health. 2021 Feb 23;18(4):2150.
- Coronavirus Disease 2019 and Stroke. Dries DJ et al. Air Med J. 2021 Mar-Apr;40(2):92-96.
- Time of Stroke Onset in Coronavirus Disease 2019 Patients Around the Globe: A Systematic Review and Analysis. Valencia-Enciso N et al. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105325.
- Treatment of unexplained coma and hypokinetic-rigid syndrome in a patient with COVID-19. Roy D et al. BMJ Case Rep. 2021 Mar 2;14(3):e239781.
- SVIN COVID-19 Multinational Registry and Task Force. Decline in mild stroke presentations and intravenous thrombolysis during the COVID-19 pandemic: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Ortega-Gutierrez S et al. Clin Neurol Neurosurg. 2021 Feb;201:106436. doi: 10.1016/j.clineuro.2020.106436. Epub 2020 Dec 15. PMID: 33383463; PMCID: PMC7836428
- Qualitative Study of Chinese Stroke Caregivers’ Caregiving Experience During the COVID-19 Pandemic. Lee JJ et al. Stroke. 2021 Feb 16:STROKEAHA120032250. Epub ahead of print. PMID: 33588588.
- Stroke Care in the First Affiliated Hospital of Chengdu Medical College during the COVID-19 Outbreak. Zhang LL et al. Eur Neurol. 2020;83(6):630-635.
- Acute Ischemic Stroke and COVID-19: An Analysis of 27 676 Patients. Qureshi AI et al. Stroke. 2021 Feb 4
- Impact of COVID-19 pandemic on acute stroke care: facing an epidemiological paradox with a paradigm shift. Paolucci M et al. Neurol Sci. 2021 Feb;42(2):399-406.
- European Multicenter Study of ET-COVID-19. Cagnazzo F et al. Stroke. 2021 Jan;52(1):31-39.
- In-Hospital Delays for Acute Stroke Treatment Delivery During the COVID-19 Pandemic. Katsanos AH et al. Can J Neurol Sci. 2021 Jan;48(1):59-65.
- Simultaneous cardio-cerebral infarction in the coronavirus disease pandemic era: A case series. Eskandarani R et al. Medicine (Baltimore). 2021 Jan 29;100(4):e24496.
- Global stroke challenges: From COVID-19 to intracerebral hemorrhage and atrial fibrillation. Markus HS. Int J Stroke. 2021 Feb;16(2):121-122.
- SVIN Multinational Registry and Task Force. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. Ramos-Araque ME et al. BMC Neurol. 2021 Jan 30;21(1):43.
- Decline and Recurrence of Stroke Consultations during the COVID-19 Pandemic Lockdown Parallels Population Activity Levels. Schlachetzki F et al. Cerebrovasc Dis. 2021 Feb 4:1-9.
- Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic. Sharma R et al. Stroke. 2021 Jan;52(2):563-572.
- Incidence, characteristics and clinical relevance of acute stroke in old patients hospitalized with COVID-19. Mendes A. et al. BMC Geriatr. 2021 Jan 14;21(1):52.
- Impact of COVID-19 on hospital admission of acute stroke patients in Bangladesh. Hasan ATMH. et al. PLoS One. 2021 Jan 13;16(1):e0240385.
- Clinical characteristics and treatment outcome of COVID-19 patients with stroke in China: A multicenter retrospective study. Ji XY. et al. Phytomedicine. 2021 Jan;81:153433.
- Neurological manifestations in COVID-19: a systematic review and meta-analysis. Chua TH. et al. Brain Inj. 2020 Oct 14;34(12):1549-1568.
- Acute Cerebrovascular Events With COVID-19 Infection. Dhamoon MS,et al. Stroke. 2021 Jan;52(1):48-56.
- Influence of the COVID-19 Pandemic on Treatment Times for Acute Ischemic Stroke: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Siegler JE. et al. Stroke. 2021 Jan;52(1):40-47.
- Impact of a Stay-at-Home Order on Stroke Admission, Subtype, and Metrics during the COVID-19 Pandemic. Rameez F. et al. Cerebrovasc Dis Extra. 2020;10(3):159-165.
- Analysis of Nationwide Stroke Patient Care in Times of COVID-19 Pandemic in Germany. Richter D et al. Stroke. 2020 Dec 24. STROKEAHA120033160.
- Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations. Chougar et al. Radiology 2020 Dec.
- Influence of the COVID-19 Pandemic on Treatment Times for Acute Ischemic Stroke: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Siegler JE et al. Stroke. 2020 Nov 30
- Stroke in COVID-19: A systematic review and meta-analysis. Nannoni S. et al. Int J Stroke. 2020 Nov 11
- Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study. Perry RJ et al. J Neurol Neurosurg Psychiatry. 2020 Nov 5.
- Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients. ESCALARD S. et al. Stroke. 2020 Aug 19.
- Intravenous thrombolysis for acute ischaemic stroke during COVID-19 pandemic in Wuhan, China: a multicentre, retrospective cohort study. Zhou Y. et al. J Neurol Neurosurg Psychiatry. 2020 Oct 28.
- Acute COVID-19 and the Incidence of Ischemic Stroke and Acute Myocardial Infarction. Modin et al. Circulation. 2020 Oct 15.
- Decreasing referrals to transient ischaemic attack clinics during the COVID-19 outbreak: results from a multicentre cross-sectional survey. D’Anna L. et al. BMJ Open. 2020 Oct 23.
- Impact of the Coronavirus Disease Pandemic on the Number of Strokes and Mechanical Thrombectomies: A Systematic Review and Meta-Analysis. July J. and Pranata R. J Stroke Cerebrovasc Dis. 2020 Nov;29(11).
- Vascular Events, Vascular Disease and Vascular Risk Factors-Strongly Intertwined with COVID-19. Scutelnic and Heldner. Curr Treat Options Neurol. 2020;22(11):40.
- Stroke Care Within the COVID-19 Pandemic—Increasing Awareness of Transient and Mild Stroke Symptoms Needed. Uphaus T. et al. Frontiers in Neurology 2020 Oct.
- Impact of COVID-19 on stroke admissions, treatments, and outcomes at a comprehensive stroke centre in the United Kingdom. Padmanabhan, N et al. Neurol Sci (2020).
- Impact of COVID-19 on Patient Behavior to Stroke Symptoms in China. Song L. et al. Cerebrovasc Dis. 2020 Oct 8
- Mechanical thrombectomy for acute ischaemic stroke during the COVID-19 pandemic: changes to UK practice and lessons learned. McConachie D. et al. Clin Radiol. 2020 Oct.
- Streamlined Poststroke Treatment Order Sets During the SARS-CoV-2 Pandemic: Simplifying While Not Compromising Care. Gioia LC et al. Stroke. 2020 Oct.
- Effect of COVID-19 Pandemic on Mechanical Thrombectomy for Acute Ischemic Stroke Treatment in United States. Qureshi AIet al. J Stroke Cerebrovasc Dis. 2020 Oct.
- Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression. Pranata R. et al. J Stroke Cerebrovasc Dis. 2020 Aug;29(8)
- Effect of COVID-19 on First-Time Acute Stroke and Transient Ischemic Attack Admission Rates and Prognosis in Denmark: A Nationwide Cohort Study. Butt JH. et al. Circulation. 2020 Sep 22.
- Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study. Shahjouei S. et al. EBioMedicine. 2020 Sept.
- Ischemic stroke in COVID-19: An urgent need for early identification and management. Jillella DV et al. PLoS One. 2020 Sep 18.
- Clinician’s Perception of Practice Changes for Stroke During the COVID-19 Pandemic. Kamdar et al. J Stroke Cerebrovasc Dis. 2020 Oct
- The effect of COVID-19 on stroke hospitalizations in New York City. Esenwa et al. J Stroke Cerebrovasc Dis. 2020 Oct
- COVID-19 Impact on Stroke Presentations. Strasser et al. Stroke Cerebrovasc Dis. 2020 Oct
- Incidence of Acute Ischemic Stroke and Rate of Mechanical Thrombectomy During the COVID-19 Pandemic in a Large Tertiary Care Telemedicine Network. Sweid et al. World Neurosurg. 2020 Aug
- Cerebrovascular Complications of COVID-19. Katz et al. Stroke. 2020 Sep
- Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19. Agarwal et al. 2020
- Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Agarwal et al. J Stroke Cerebrovasc Dis. 2020 Sep;29
- Initial Stroke Thrombectomy Experience in New York City during the COVID-19 Pandemic. Yaeger et al. AJNR Am J Neuroradiol. 2020 Aug
- Emergent Large Vessel Occlusion Stroke During New York City’s COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings. Majidi et al. Stroke. 2020 Sep
- Acute Cerebrovascular Events in Hospitalized COVID-19 Patients. Rothstein et al. Stroke. 2020
- Stroke risk, phenotypes, and death in COVID-19: Systematic review and newly reported cases. Fridman et al. Neurology. 2020 Sep
- Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic. Barlinn et al. J Stroke Cerebrovasc Dis. 2020 Sep
- Ischaemic stroke associated with COVID-19 and racial outcome disparity in North America. Dmytriw et al. J Neurol Neurosurg Psychiatry. 2020 Aug
- . Böjti et al. Orv Hetil. 2020 Aug
- Telestroke in the Time of COVID-19: The Mayo Clinic Experience. Huang et al. Mayo Clin Proc. 2020 Aug
- Acute Stroke in Times of the COVID-19 Pandemic: A Multicenter Study Hoyer et al. Stroke. 2020 Jul
- Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak. Decreased Activity, and Increased Care Delays Kerleroux et al. Stroke. 2020 Jul
- Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke Choi et al. Biochem Biophys Res Commun. 2020 Jul
- COVID-19 is an Independent Risk Factor for Acute Ischemic Stroke. Belani et al. AJNR. Jun 2020
- Potential Indirect Effects of the COVID-19 Pandemic on Use of Emergency Departments for Acute Life-Threatening Conditions – United States, January-May 2020 . Lange et al. MMWR 2020 Jun 26
- Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study Varatharaj et al. The Lancet Psychiatry 2020 Jun
- Cerebrovascular Events in Hospitalized COVID-19 Patients Mishra et al. Monaldi Arch Chest Dis. 2020 Jun
- Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature. Aggarwal et al. Int J Stroke. 2020 Jun
- Decrease in Hospital Admissions for Transient Ischemic Attack, Mild, and Moderate Stroke During the COVID-19 Era. Diegoli et al. Stroke. 2020 Jun
- Maintaining stroke care in Europe during the COVID-19 pandemic: Results from an international survey of stroke professionals and practice recommendations from the European Stroke Organisation. Aguiar de Sousa et al. ESJ. 2020 Jun
- Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19. Paranjpe et al. JACC 2020.
- COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome Jain et al. J Neurol Sci. 2020 Jul
- Emergency ambulance services for heart attack and stroke during UK’s COVID-19 lockdown. Holmes et al. Lancet. 2020 May
- Delays in Stroke Onset to Hospital Arrival Time During COVID-19. Teo et al. Stroke 2020 May
- Break in the Stroke Chain of Survival Due to COVID-19, Montaner, et al. Stroke. 2020 May
- Impact of the COVID-19 Epidemic on Stroke Care and Potential Solutions . Zhao et al. Stroke. 2020 May
- Acute Stroke Care Is at Risk in the Era of COVID-19: Experience at a Comprehensive Stroke Center in Barcelona, Rudilosso et al. Stroke. 2020 May.
- Prehospital Triage of Acute Stroke Patients During the COVID-19 Pandemic. Goyalfs et al. Stroke. 2020 May 13.
- Delayed presentation of acute ischemic strokes during the COVID-19 crisis Endovascular Research Group (ENRG). Schirmer et al. J Neurointerv Surg. 2020 Jul
- SARS2-CoV-2 and Stroke in a New York Healthcare System. Yaghi et al Stroke. 2020 May
- Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Mehra et al. N Engl J Med. 2020 May
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. Oxley et al. N Engl J Med. 2020 May 14
- Impact of the COVID-19 pandemic on the process and outcome of thrombectomy for acute ischemic stroke Yang et al. J Neurointerv Surg. 2020 May
- Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris. Escalard et al. Stroke. 2020 May
- Clinical Characteristics and Outcomes of COVID-19 Patients With a History of Stroke in Wuhan, China. Qin et al Stroke. 2020 May
- OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients The OpenSAFELY Collaborative.
- Characteristics of ischaemic stroke associated with COVID-19 Beyrouti et al. JNNP. 2020 Apr
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China Mao et al. JAMA Neurol. 2020 April
- Acute Cerebrovascular Disease Following COVID-19: A Single Center, Retrospective, Observational Study. Yanan et al. 2020 Mar
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The collected publications have been suggested by members of the Paper of the Month working group. ESO members can also nominate a paper for inclusion in this resource.
Stroke Alliance For Europe (SAFE)
European Academy of Neurology (EAN)
European Society Of Cardiology (ESC)