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Welcome
ESO continues to update our curated collection of resources relevant for the treatment of stroke during the COVID-19 global pandemic. We hope you will find this page valuable. #StrokeStillMatters
As further publications and studies emerge, this resource continues to grow. Please check back at the end of each month for the most recent publications. We encourage submissions of COVID-19 resources to be considered for inclusion. Please send the source and link to esoinfo@eso-stroke.org.
Stroke and COVID-19
Registries and Open Studies
If you are looking to recruit participants for registries or studies and would like to announce them here, please contact us at esoinfo@eso-stroke.org.
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Publications Relevant for Stroke Diagnosis and Management
Updated May 2021
COVID-19 Vaccination and Cerebrovascular Events
Original Articles/Case Reports - AstraZeneca Vaccine
- Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopaenia. Al-Mayhani T. et al. Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 May 2021.
- Castelli G.P. et al. Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19. Crit Care. 2021 Apr 12;25(1):137. .
- See I. et al. US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. JAMA. Published online April 30, 2021.
- Pottegård A. et al. Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study. BMJ. 2021 May 5;373:n1114.
- Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. Scully M. et al. N Engl J Med. 2021 Apr 16.
- Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. Greinacher A et al. N Engl J Med. 2021 Apr 9.
- Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. Schultz N.H. et al. N Engl J Med. 2021 Apr 9.
- Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). Greinacher A. et al.
Original Articles / Case Reports - Johnson and Johnson/Janssen Vaccine
- Advisory Committee on Immunization Practices. Reports of cerebral venous sinus thrombosis with thrombocytopenia after Janssen COVID-19 vaccine. National Center for Immunization & Respiratory Diseases. . April 12, 2021
- Thrombotic thrombocytopenia after Ad26.COV2.S vaccination. Muir K-L et al. N Engl J Med.
- Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – Response from the Manufacturer. Sadoff J. et al. N Engl J Med. 2021 Apr 16.
Original Articles / Case Reports - Moderna Vaccine
- Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine. Helms J.M. et al. J Blood Med. 2021 Apr 6;12:221-224.
- Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Bayas A. et al. . Lancet. 2021;S0140-6736(21)00872-2.
- Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. Guendouz C. et al. Medicine (Baltimore). 2021 Mar 12;100(10):e24708.
Original Articles / Case Reports - Pfizer/Biontech Vaccine
Guidance
- American Heart Association/American Stroke Association Stroke Council Leadership. Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia. Stroke. 2021 Apr 29.
- Oldenburg J. et al. Diagnosis and management of vaccine-related thrombosis following astrazeneca covid-19 vaccination: Guidance statement from the GTH. Hamostaseologie. 2021.
- UK Guidance produced by the Expert Haematology Panel (EHP) focussed on Vaccine induced Thrombosis and Thrombocytopenia (VITT)
- UK Management of cerebral venous sinus thrombosis following Covid-19 vaccination A neurosurgical guide
Comments and Editorials
- SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. Cines D.B. et al. N Engl J Med. 2021 Apr 16.
- Douxfils J. et al. Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination. Thromb Res. 2021 Jul;203:163–71.
Venous thromboembolism after vaccination or COVID-19
Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry Giannis et al. Preprint as .pdf
Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. Taquet M et al. Preprint
Additional Publications on COVID-19 and Stroke
- Mohamad A. et al. Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature,
Journal of Stroke and Cerebrovascular Diseases, Volume 30, Issue 6, 2021 - Wallace A.N. et al. Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes During the Early COVID-19 Pandemic. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105569.
- McAlpine L.S. et al. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. Stroke. 2021 Jun;52(6):e233-e238.
- Shahjouei S. et al. SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group. 2021 May;52(5):e117-e130.
- Abdalkader M. et al. Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105733.
- Douiri A. et al. SSNAP Collaboration. Stroke Care in the United Kingdom During the COVID-19 Pandemic. Stroke. 2021 Apr 26:STROKEAHA120032253.
- Yamal J.M. et al. Successful conduct of an acute stroke clinical trial during COVID. PLoS One. 2021 Jan 15;16(1):e0243603.
- Harrison S.L et al. Higher Mortality of Ischaemic Stroke Patients Hospitalized with COVID-19 Compared to Historical Controls. Cerebrovasc Dis. 2021 Mar 26:1-6.
- Shahjouei S. et al. SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group. Stroke. 2021 May;52(5):e117-e130.
- Kovalchuk V.V. et al. Vozmozhnosti povysheniya effektivnosti terapii patsientov s khronicheskoi ishemiei golovnogo mozga na fone COVID-19 [Possibilities of improving the effectiveness of therapy in patients with chronic cerebral ischemia against the background of COVID-19]. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(3. Vyp. 2):60-66. Russian.
- Reddy S.T. et al. A meta-analysis of the global impact of the COVID-19 pandemic on stroke care & the Houston Experience. Ann Clin Transl Neurol. 2021 Apr;8(4):929-937.
- Honardoost M. et al. The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2021;50(2):132-140.
- Kwan J. et al. Impact of COVID-19 Pandemic on a Regional Stroke Thrombectomy Service in the United Kingdom. Cerebrovasc Dis. 2021;50(2):178-184.
- Koncz J. et al. SARS-Cov-2-fertőzés szövődményeként kialakult enormis nagyságú carotisthrombus kezelési lehetőségei [Treatment options for enormous carotid thrombus as a complication of SARS-CoV-2 infection]. Ideggyogy Sz. 2021 Mar 30;74(3-4):129-134. Hungarian.
- Kusztal M. et al. Is home-based therapy in Fabry disease the answer to compelling patients’ needs during the COVID-19 pandemic? Survey results from the Polish FD Collaborative Group. Adv Clin Exp Med. 2021 Apr;30(4):449-454.
- Tu T.M. et al. Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men. JAMA Netw Open. 2021 Apr 1;4(4):e217498.
- Honardoost M. et al. The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2021;50(2):132-140.
The collected publications have been suggested by members of the Paper of the Month working group. ESO members can also nominate a paper for inclusion in this resource.
